Abstract:

Choroidal neovascularization (CNV) occurred in many ocular fundus diseases and has become one of the main cause of visual disability. The abnormal regulation of many intracellular signal transduction pathways are involved in the occurrence and development of CNV. Recently many researches have shown that many signaling pathways including PI3K/Akt, Wnt, STAT3, Notch, etc. play the essential roles in the development of CNV. Researches on these signaling pathways in CNV may contribute to the illumination of pathogenic mechanism of CNV and the searches for new therapeutic targets.